The manipulation of microRNA-gene regulatory networks by KSHV induces endothelial cell motility
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چکیده
The manipulation of microRNA-gene regulatory networks by KSHV induces endothelial cell motility Yu-Hsuan Wu, Tzu-Fang Hu, Yu-Chieh Chen, Ya-Ni Tsai, Yuan-Hau Tsai, Cheng-Chung Cheng and Hsei-Wei Wang Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan; VGH-YM Genome Center, National Yang-Ming University, Taipei, Taiwan; Division of Cardiology, Department of Medicine, Tri-Service General Hospital, Taipei, Taiwan; Department of Education and Medical Research, Taipei City Hospital, Taipei, Taiwan.
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The manipulation of miRNA-gene regulatory networks by KSHV induces endothelial cell motility.
miRNAs have emerged as master regulators of cancer-related events. miRNA dysregulation also occurs in Kaposi sarcoma (KS). Exploring the roles of KS-associated miRNAs should help to identify novel angiogenesis and lymphangiogenesis pathways. In the present study, we show that Kaposi sarcoma-associated herpesvirus (KSHV), the etiological agent of KS, induces global miRNA changes in lymphatic end...
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